Healthy Buffalo Chicken Spaghetti Squash Casserole Recipe

If you’re craving something packed with vibrant flavors yet nourishing enough to feel good about, this Healthy Buffalo Chicken Spaghetti Squash Casserole is about to become your new go-to comfort food. This delicious casserole takes the humble spaghetti squash and transforms it into a creamy, spicy, and protein-rich masterpiece that’s both light and satisfying. Combining juicy shredded chicken, zesty buffalo sauce, and melty mozzarella with the natural texture of spaghetti squash, this dish beautifully balances indulgence and health without sacrificing taste. From weeknight dinners to casual gatherings, it’s a dish that promises crowd-pleasing warmth and a welcome kick of buffalo heat.

Ingredients You’ll Need

Each ingredient in this recipe plays an essential role, creating layers of flavor, texture, and color that make this casserole irresistible. The simplicity of the lineup means you can often find everything in your pantry or fridge, while each component adds something unique—from the mild sweetness of red pepper to the tangy brightness of lime juice.

• Spaghetti Squash: This low-carb veggie is the perfect substitute for pasta, offering a mild flavor and satisfying stringy texture.
• Red Pepper: Adds a fresh crunch and a subtle sweetness that contrasts beautifully with spicy elements.
• Shredded Chicken: Use rotisserie or homemade chicken for tender, protein-packed goodness that soaks up all the buffalo sauce.
• Egg: Acts as a binder to hold everything together in perfect casserole form.
• Lime Juice: Provides a bright, zesty punch that lifts the richness of the dish.
• Honey: Balances the heat with a touch of natural sweetness.
• Garlic Powder and Onion Powder: These pantry staples add depth and savory warmth.
• Frank’s Buffalo Sauce: Delivers that iconic tangy heat, which is the heart of this casserole’s bold flavor.
• Plain 0% Greek Yogurt: A creamy, protein-rich alternative to sour cream that adds smoothness and tang.
• Mozzarella Cheese: Melts into gooey perfection, binding everything and providing satisfying richness.
• Optional Toppings (Blue Cheese or Feta, Green Onion): These add an extra layer of creaminess and a fresh, peppery bite to finish the dish beautifully.

How to Make Healthy Buffalo Chicken Spaghetti Squash Casserole

Step 1: Cook Your Spaghetti Squash

If you haven’t cooked the spaghetti squash yet, it’s an important first step. Slice it in half lengthwise, scoop out the seeds, drizzle with olive oil and a pinch of salt, and roast it cut side down on a parchment-lined baking sheet at 375°F for around 30 to 40 minutes. Once it’s tender, run a fork through the flesh to create those lovely spaghetti-like strands that form the base of this casserole.

Step 2: Prepare the Buffalo Sauce Mixture

In a large mixing bowl, whisk together the egg, lime juice, honey, garlic powder, and onion powder. If you used homemade chicken, season it lightly with salt and pepper now to layer in flavor. Then stir in the buffalo sauce and Greek yogurt. This mixture is where the magic happens, delivering creaminess with a kick that ties the whole dish together.

Step 3: Combine Ingredients for the Casserole

Fold the roasted spaghetti squash, diced red pepper, shredded chicken, and a quarter cup of mozzarella cheese into the buffalo sauce mixture. Using a wooden spoon to gently combine everything ensures that all the flavors meld beautifully without mashing the squash strings.

Step 4: Bake Until Melty and Golden

Transfer the filling to a greased 9×13-inch baking dish and sprinkle the remaining mozzarella cheese on top. Bake in a 400°F oven for 20 to 25 minutes until the cheese is bubbling and golden on the edges. After baking, let it cool slightly to allow the casserole to set up for easier serving.

How to Serve Healthy Buffalo Chicken Spaghetti Squash Casserole

Garnishes

Topping your casserole with crumbled blue cheese or feta adds a wonderfully tangy creaminess that complements the buffalo heat perfectly. Sliced green onions add a pop of fresh color and a mild onion bite that brightens every bite. These simple garnishes elevate both the flavor and presentation effortlessly.

Side Dishes

This casserole stands strong on its own, but offering a crisp, refreshing side salad with lemon vinaigrette or crunchy celery sticks can cut through the richness and add balance to your meal. Roasted seasonal vegetables also make a fantastic accompaniment, giving you more colors and textures on your plate.

Creative Ways to Present

For a fun twist, serve the casserole in individual ramekins for personal portions that look gorgeous on any table. Alternatively, scoop it onto large lettuce leaves or stuffed into bell pepper halves to make enticing, hand-held bites perfect for casual gatherings. A sprinkle of extra herbs like chopped parsley or cilantro can bring a fresh, vibrant pop.

Make Ahead and Storage

Storing Leftovers

Leftover Healthy Buffalo Chicken Spaghetti Squash Casserole can be stored in an airtight container in the refrigerator for up to 3 days. It holds its flavors beautifully, making for an easy and satisfying next-day lunch or dinner option.

Freezing

This casserole freezes well, which is perfect for meal prepping. Portion it into freezer-safe containers and freeze for up to 2 months. Thaw overnight in the fridge before reheating for best results, maintaining that creamy, spicy goodness.

Reheating

To reheat, warm individual portions in the microwave or oven until heated through. Covering with foil in the oven prevents the top from over-browning while ensuring the casserole heats evenly. Add a sprinkle of extra cheese or garnish after reheating to revive that fresh, just-baked feeling.

FAQs

Can I use a different type of cheese instead of mozzarella?

Absolutely! While mozzarella melts beautifully, you can substitute with cheddar, Monterey Jack, or even a blend of cheeses to tailor the dish to your personal taste.

Is there a way to make this casserole dairy-free?

Yes! Swap the mozzarella for a dairy-free cheese alternative, and replace Greek yogurt with a plant-based yogurt. Using buffalo sauce that’s free of dairy ensures you keep that bold flavor without compromises.

Can I make this recipe vegetarian?

Definitely. Replace the chicken with hearty roasted vegetables or plant-based chicken alternatives. Adding extra beans or lentils can also boost protein without sacrificing texture.

How spicy is this casserole?

The heat level depends largely on the buffalo sauce you use. Frank’s Buffalo Sauce provides a medium heat that balances well with the creamy yogurt and cheese, but feel free to adjust the amount to suit your preference.

What’s the best way to cook spaghetti squash for this recipe?

Roasting with the cut side down is a popular method that yields tender strands with a slightly nutty flavor. You can also microwave the squash for a quicker option, but roasting enhances the texture and flavor most effectively.

Final Thoughts

This Healthy Buffalo Chicken Spaghetti Squash Casserole is a perfect example of comfort food that doesn’t compromise on health or flavor. Rich, creamy, spicy, and packed with wholesome ingredients, it’s a recipe you’ll want to make again and again. Once you try it, you’ll see why it’s become such a beloved favorite — so go ahead and dive into this deliciously satisfying dish that brings warmth and a kick to every bite!

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